Examinando por Materia "Aging"
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Ítem Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart(Elsevier BV, 2012-02-01) Gómez, Luis A.; Du Heath, Shi-Hua; Hagen, Tory M.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)The aging heart displays a loss of bioenergetic reserve capacity partially mediated through lower fatty acid utilization. We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least partially, through diminished leÍtem Age-related decline in mitochondrial bioenergetics: Does supercomplex destabilization determine lower oxidative capacity and higher superoxide production(Copyright, 2012-09-01) Gómez, Luis A.; Hagen, Tory M.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)Mitochondrial decay plays a central role in the aging process. Although certainly multifactorial in nature, defective operation of the electron transport chain (ETC) constitutes a key mechanism involved in the age-associated loss of mitochondrial energy mÍtem Análisis de los programas de adulto mayor en Sabaneta y sus beneficios en la salud física, cognitiva y psicológica(Universidad EAFIT, 2023) Sánchez Henao, Natalia; Jiménez Londoño, Laura María; Ceballos García, Grey YulietÍtem Calidad de vida del adulto mayor en Medellín 2001-2017 : una mirada desde las estrategias estatales(Universidad EAFIT, 2018) Echavarría López, Yesica; Tobón Lotero, Juan DiegoThe public strategies in regard of the quality of life for older people first appeared in 2001 with the Public Policy created for this population. Although there was a series of municipal changes that allowed us to think about the increase of older people, such as life expectancy and the decrease in birth rates, these transformations in the society had effects in the construction of some plans and strategies to serve this population in the last two decades. The purpose of this article is to analyze the strategies that emerged between 2001 and 2017 in relation to the elders and its articulation with the Municipal Development Plans. At the same time, it generates a discussion about the challenges, difficulties, needs and possible lines of action that arises at the work with older people in a mobile and dynamic context. This review shows that, according to the reviewed sources, the strategies have been essentially the same, and there have been very little plans proposing new interventions in accordance with the changes this population have had. In addition to this, most plans involve dealing with elders who have socio-economical difficulties, while people with other difficulties are left out. Additionally, there is no culture of aging in the city on how to deal with this natural period of life.Ítem Contribution of Root Canal Treatment to the Fracture Resistance of Dentin(Elsevier Inc., 2019-01-01) Yan W.; Montoya C.; Øilo M.; Ossa A.; Paranjpe A.; Zhang H.; Arola D.D.; Yan W.; Montoya C.; Øilo M.; Ossa A.; Paranjpe A.; Zhang H.; Arola D.D.; Universidad EAFIT. Departamento de Ingeniería de Producción; Materiales de IngenieríaIntroduction: Although the strength and toughness of dentin decrease with age, no study has explored if restorative treatments are a contributing factor. Methods: Multiple extracted teeth were obtained from randomly selected donors and categorized according to donor age and prior root canal treatment. The microstructure and chemical composition of radicular dentin were evaluated using scanning electron microscopy and Raman spectroscopy, respectively, and the strength was evaluated in 4-point flexure to failure. Data were compared using the Student t test. Results: Dentin from the root canal–restored teeth exhibited significantly lower strength (P <.05) than tissue from age- and donor-matched unrestored tooth pairs. Although there was no significant difference in the mineral-to-collagen ratio between the 2 groups, dentin obtained from the root canal–treated teeth exhibited more extensive collagen cross-linking and lower tubule occlusion ratios than the unrestored tooth pairs. Conclusions: There is a decrease in the strength of radicular dentin with aging, but prior root canal treatment increases the extent of degradation. © 2018 American Association of EndodontistsÍtem Deformation behaviour of aged coronal dentin(Blackwell Munksgaard, 2018-06-01) Montoya; C.; Arola; D.; Ossa; E.A.; Universidad EAFIT. Departamento de Ingeniería de Producción; Materiales de IngenieríaObjective: This study aimed to identify the changes in the time-dependent deformation response of coronal dentin with ageing and its relationship with changes in chemical composition. Background: The structural behaviour of dentin with ageing is affected by changes in the density and diameter of its dentinal tubules (ie porosity), as well as changes in chemical composition throughout the tooth. However, little is known about the time-dependent deformation behaviour of aged dentin and the importance of its hierarchical structure and variations in chemical composition. Materials and methods: The spherical indentation response of aged coronal dentin was analysed in the outer, middle and inner regions, and its time-dependent deformation response was modelled in terms of its microstructure and chemical composition using a model recently proposed for young dentin. Results: The viscous deformation behaviour of aged dentin followed a power-law response with a decrease in the stress exponent when compared to young dentin. These results can be explained by cross-linking of the collagen present in the tissue. Conclusion: A decrease in the deformation ability of aged dentin was found. This behaviour could be a result of a dissolution process and reprecipitation of the minerals present in intertubular dentin into the dentinal tubules. © 2018 John Wiley & Sons A/S and The Gerodontology Association. Published by John Wiley & Sons LtdÍtem Dynamics of the Korean population since 1960 and its relationship with the demographic transition(Universidad EAFIT, 2016-06-30) Toro Restrepo, Sebastian; Palacios Murillo, Eumary; Universidad EAFITÍtem Envejecimiento termo-oxidativo de asfaltos(Universidad EAFIT, 2014) Gamarra Escamilla, AdrianaÍtem Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age(Elsevier Inc., 2014-07-01) Gómez, Luis A.; Smith, Eric J.; Butler, Judy A.; Moreau, Regis; Hagen, Tory M.; Finlay, Liam A.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults.Ítem (R)-alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria(Elsevier Inc., 2011-01-01) Monette, Jeffrey S.; Gómez, Luis A.; Moreau, Regis; Dunn, Kevin C.; Butler, Judy A.; Finlay, Liam A.; Michels, Alexander J.; Petersen-Shay, Kate; Smith, Eric J.; Hagen, Tory M.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display many of these characteristics, we hyÍtem Reduction in Fracture Resistance of the Root with Aging(Elsevier Inc., 2017-09-01) Yan W.; Montoya C.; Øilo M.; Ossa A.; Paranjpe A.; Zhang H.; Arola D.; Yan W.; Montoya C.; Øilo M.; Ossa A.; Paranjpe A.; Zhang H.; Arola D.; Universidad EAFIT. Departamento de Ingeniería de Producción; Materiales de IngenieríaIntroduction: The incidence of vertical root fracture in endodontically treated teeth increases with patient age. This study evaluated the microstructure, chemical composition, and mechanical properties of radicular dentin as a function of aging. Methods: Single-rooted teeth were obtained from adult donors ranging from age 15 to older than 80 years. Beams were extracted from the middle third of the root and subjected to 4-point flexure to failure to evaluate strength of dentin in terms of donor age. Based on the strength distribution, the fatigue strength of root tissue from young (<= 30 years) and old (>= 55 years) donor teeth was evaluated via cyclic flexure loading. The microstructure and chemical composition of radicular dentin from the 2 groups were evaluated as a function of distance from the root apex using microscopy and Raman spectroscopy, respectively. Results: The strength decreased with age by approximately 25 MPa per decade, which resulted in a significant difference (P <= .0001) between the young (199 +/- 36 MPa) and old (122 +/- 11 MPa) groups. There was also a significant difference (P <= .0001) in fatigue strength between the young and old age groups. Both the mineral-to-collagen ratio and degree of cross-linking increased with age, with the largest changes identified in the apical and middle thirds, respectively. Conclusions: There is a reduction in the damage tolerance of radicular dentin with increasing age. This degradation appears to result from changes in the microstructure, corresponding chemical composition, and increase in collagen cross-linking with age, and is most severe near the root apex.Ítem Las representaciones sociales de la vejez y el envejecimiento en dos grupos de mujeres : jóvenes y adultas mayores de la U. Eafit de Medellín.(2018) Miranda Ávila, Laura Alejandra; Gálvez Ortiz, Claudia Alejandra VictoriaThe present investigation was carried out during the years 2017 and 2018. The part of the concept of social representations about old age and aging as the way to obtain the knowledge of the conventional reality and accessible to a common sense as a socially elaborated production, like a starting point of the meaning arising from social interaction. The information was obtained from surveys, interviews and observation of groups of women: young people from 18 to 25 years old and older than 50 to 60 years of the Eafit University, based on a qualitative approach. The main findings indicate that there is a difference in relation to perception, attitude and the figurative core with respect to the current moment of life, and that it is not the same to be in the stage of youth to the stage of old age. In addition, the difficulty of generalizing the characteristics of life in human beings must be taken into account, just as each person reaches adulthood with the various learning activities acquired in the socio-cultural contexts in which they develop. The characteristics that appear in the relationship between psychological functions and cognitive functions are shown differently in each individualÍtem Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart(ELSEVIER SCIENCE INC, 2009-10-01) Gómez, Luis A.; Monette, Jeffrey S.; Chavez, Juan D.; Maier, Claudia S.; Hagen, Tory M.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)Accumulation of mitochondrial electron transport chain (ETC) defects is a recognized hallmark of the age-associated decline in cardiac bioenergetics; however, the molecular events involved are only poorly understood. In the present work,