Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart
Fecha
2012-02-01
Autores
Gómez, Luis A.
Du Heath, Shi-Hua
Hagen, Tory M.
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Editor
Elsevier BV
Resumen
The aging heart displays a loss of bioenergetic reserve capacity partially mediated through lower fatty acid utilization. We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least partially, through diminished le