(R)-alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria
Fecha
2011-01-01
Autores
Monette, Jeffrey S.
Gómez, Luis A.
Moreau, Regis
Dunn, Kevin C.
Butler, Judy A.
Finlay, Liam A.
Michels, Alexander J.
Petersen-Shay, Kate
Smith, Eric J.
Hagen, Tory M.
Título de la revista
ISSN de la revista
Título del volumen
Editor
Elsevier Inc.
Resumen
Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display many of these characteristics, we hy