Analysis of TYK2 P1104A variant in a cohort of colombian patients with pulmonary tuberculosis

Vista sencilla de ítem
dc.contributor.advisorArias Sierra, Andrés Augustospa
dc.contributor.advisorBarrera Robledo, Luis Fernandospa
dc.contributor.authorGuzmán Zuluaga, Laura Cristina
dc.coverage.spatialMedellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degreeseng
dc.creator.degreeBiólogo(a)spa
dc.creator.emaillguzma14@eafit.edu.cospa
dc.date.accessioned2021-02-18T20:33:48Z
dc.date.available2021-02-18T20:33:48Z
dc.date.issued2020
dc.description.abstractTuberculosis continues to be one of the main causes of death worldwide with around 10 million people infected annually, which is a direct problem for public health. Data that has accumulated over decades suggests that variability in human susceptibility to tuberculosis disease has a strong genetic component. Both primary and acquired immunodeficiencies (PID) are strongly related to broad infectious phenotypes that include the full range of diseases caused by the infectious agent Mycobacterium tuberculosis. Recently it was found that a PID found in up to 1/600 individuals of European descent, in fact a variant was found that affects the catalytic activity of TYK2 therefore selectively alters the immunity to IFN-g mediated by IL-23 while the responses to IL-10, IL-12, and IFN-a / b are intact. These PIDs are only expressed symptomatically after exposure to Mycobacterium tuberculosis. However, we hypothesize that homozygous for the P1104A variant or compound heterozygosity in this same TYK2 gene can confer a selective response, thus predisposing to TB. This study intends to 1. Identify the variant P1104A of the TYK2 gene in Colombian patients with pulmonary tuberculosis, 2. Identify other rare or common variants in the TYK2 gene in patients with pulmonary tuberculosis, 3. Correlating data from the Colombian population with what has been found in other populations.spa
dc.formatapplication/pdfeng
dc.identifier.ddc616.995 G993
dc.identifier.urihttp://hdl.handle.net/10784/25555
dc.language.isospaspa
dc.publisherUniversidad EAFITspa
dc.publisher.departmentEscuela de Ciencias. Ciencias Básicasspa
dc.publisher.placeMedellínspa
dc.publisher.programBiologíaspa
dc.rightsTodos los derechos reservadosspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.localAcceso abiertospa
dc.subjectMycobacterium Tuberculosisspa
dc.subjectGen TYK2spa
dc.subjectInmunodeficiencias primariasspa
dc.subjectRespuesta inmunespa
dc.subjectSusceptibilidad a tuberculosisspa
dc.subjectGenotiposspa
dc.subject.lembMICROORGANISMOSspa
dc.subject.lembMICROBIOLOGÍAspa
dc.subject.lembSALUD PÚBLICAspa
dc.subject.lembINMUNODEFICIENCIAspa
dc.subject.lembPARÁMETROS GENÉTICOSspa
dc.subject.lembENFERMEDADES DE LOS PULMONESspa
dc.subject.lembTUBERCULOSISspa
dc.titleAnalysis of TYK2 P1104A variant in a cohort of colombian patients with pulmonary tuberculosisspa
dc.typeinfo:eu-repo/semantics/bachelorThesiseng
dc.typebachelorThesiseng
dc.type.hasVersionacceptedVersioneng
dc.type.localTrabajo de gradospa

Archivos

Bloque original
Mostrando 1 - 3 de 3
No hay miniatura disponible
Nombre:
LauraCristina_GuzmanZuluaga_2020.pdf
Tamaño:
915.27 KB
Formato:
Adobe Portable Document Format
Descripción:
Trabajo de grado
Descargar
No hay miniatura disponible
Nombre:
formulario_autorizacion_publicacion_obras.pdf
Tamaño:
590.68 KB
Formato:
Adobe Portable Document Format
Descripción:
Formulario de autorización de publicación de obras
Descargar
No hay miniatura disponible
Nombre:
carta_aprobacion_trabajo_grado_eafit.pdf
Tamaño:
95.31 KB
Formato:
Adobe Portable Document Format
Descripción:
Carta de aprobación de tesis de grado
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
2.5 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Biología (trabajo de grado)