Publicación:
Inferring tumor age from multiple neutral evolutionary process

Vista sencilla de ítem
dc.contributor.advisorPulido Tamayo, Sergio
dc.contributor.authorLondoño Muñoz, Susana
dc.coverage.spatialMedellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degreeseng
dc.creator.emailslondo50@eafit.edu.cospa
dc.date.accessioned2019-11-29T16:54:55Z
dc.date.available2019-11-29T16:54:55Z
dc.date.issued2019
dc.description.abstractBackground: All cancer arise as a result of a somatic mutation, several models have been developed to understand cancer, it has been seen as an evolutionary process in which somatic mutations are the pieces of the puzzle. Somatic mutation catalogue of the cancer genome has been used to reconstruct cancer phylogeny, in this case somatic mutations without selective pressure will help determine the age of a tumor. Results: Any type of mutation can have an impact on the cell, the majority of them are neutral, mutations that have less functional impact, that means less selective pressure on the tumor evolution are the ones used as temporal measurement of the tumors. A positive correlation was found between two types of measurements, which shows that an appropriate age can be extracted using both of them. Conclusion: The use of this method can be coupled with other cancer analysis, for example, along with co-occurrence and mutual exclusivity analysis could bring a better understanding of the tumor, an appropriate tumor classification and with this a more accurate clinical decision, which leads to an efective treatment.spa
dc.description.degreelevelTrabajospa
dc.description.degreenameBiólogo(a)spa
dc.format.mimetypeapplication/pdf
dc.identifier.ddc616.994 L864
dc.identifier.instnameinstname:Universidad EAFIT
dc.identifier.reponamereponame:Repositorio Institucional Universidad EAFIT
dc.identifier.repourlrepourl:https://repository.eafit.edu.co
dc.identifier.urihttps://hdl.handle.net/10784/14908
dc.language.isospa
dc.publisherUniversidad EAFITspa
dc.publisher.departmentCiencias Básicasspa
dc.publisher.facultyEscuela de Cienciasspa
dc.publisher.placeMedellínspa
dc.publisher.programBiologíaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2
dc.rights.localAcceso abierto
dc.subjectProceso evolutivo neutral múltiplespa
dc.subjectTumorspa
dc.subjectCáncerspa
dc.subjectMutaciones somáticasspa
dc.subjectEdad del tumorspa
dc.subject.keywordTumorspa
dc.subject.keywordMultiple neutral evolutionary processspa
dc.subject.keywordCancerspa
dc.subject.keywordSomatic mutationsspa
dc.subject.keywordTumor agespa
dc.subject.lembPATOLOGÍA MOLECULARspa
dc.subject.lembCÁNCER - ASPECTOS MOLECULARESspa
dc.subject.lembNEOPLASMASspa
dc.subject.lembDIVERSIDAD DE ANTICUERPOSspa
dc.titleInferring tumor age from multiple neutral evolutionary process
dc.typeinfo:eu-repo/semantics/bachelorThesis
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localTrabajo de gradospa
dc.type.redcolhttp://purl.org/redcol/resource_type/TP
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Susana_Londoño_Sergio_Pulido_2019.pdf
Tamaño:
142.05 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Biología (trabajo de grado)