Examinando por Autor "Monette, Jeffrey S."
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Ítem Characteristics of the Rat Cardiac Sphingolipid Pool in Two Mitochondrial Subpopulations(Elsevier Inc., 2010-06-01) Monette, Jeffrey S.; Gómez, Luis A.; Moreau, Regis; Taylor, Alan; Hagen, Tory M.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)Mitochondrial sphingolipids play a diverse role in normal cardiac function and diseases, yet a precise quantification of cardiac mitochondrial sphingolipids has never been performed. Therefore, rat heart interfibrillary mitochondria (IFM) and subsarcolemmÍtem (R)-alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria(Elsevier Inc., 2011-01-01) Monette, Jeffrey S.; Gómez, Luis A.; Moreau, Regis; Dunn, Kevin C.; Butler, Judy A.; Finlay, Liam A.; Michels, Alexander J.; Petersen-Shay, Kate; Smith, Eric J.; Hagen, Tory M.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display many of these characteristics, we hyÍtem Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart(ELSEVIER SCIENCE INC, 2009-10-01) Gómez, Luis A.; Monette, Jeffrey S.; Chavez, Juan D.; Maier, Claudia S.; Hagen, Tory M.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)Accumulation of mitochondrial electron transport chain (ETC) defects is a recognized hallmark of the age-associated decline in cardiac bioenergetics; however, the molecular events involved are only poorly understood. In the present work,