Controlled drug release from a spheroidal matrix

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dc.citation.journalTitlePHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
dc.contributor.authorSimon L.
dc.contributor.authorOspina J.
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon L.
dc.creatorOspina J.
dc.date.accessioned2021-03-26T21:32:06Z
dc.date.available2021-03-26T21:32:06Z
dc.date.issued2019-01-01
dc.description.abstractDrug transport through a spheroidal matrix was studied using Fick's second law of diffusion in spherical coordinates. The prolate spheroid-shaped geometry was described by a small angular deformation applied at the surface of the body. An infinite series of Legendre polynomials of order two was first used to develop an expression for the solute concentration in the Laplace domain. This method resulted in closed-form expressions for the effective time constant and the cumulative percentage of drug released in terms of critical model parameters. The procedure predicted published solutions very well. More moisture was observed at the center of the body when compared to the focal point. As the aspect ratio increased, the effective time constant decreased. At 0.38 unit time, 98.6% of the loaded drug was released from the device. © 2018 Elsevier B.V.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8517
dc.identifier.doi10.1016/j.physa.2018.11.048
dc.identifier.issn03784371
dc.identifier.issn18732119
dc.identifier.otherWOS;000456359200004
dc.identifier.otherSCOPUS;2-s2.0-85057841625
dc.identifier.urihttp://hdl.handle.net/10784/27352
dc.languageeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85057841625&doi=10.1016%2fj.physa.2018.11.048&partnerID=40&md5=c49d64a29020a8a9fde698cfd00be96a
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0378-4371
dc.sourcePHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
dc.subjectAspect ratioeng
dc.subjectComputational mechanicseng
dc.subjectLaplace transformseng
dc.subjectTargeted drug deliveryeng
dc.subjectAngular deformationeng
dc.subjectClosed-form expressioneng
dc.subjectControlled drug releaseeng
dc.subjectControlled releaseeng
dc.subjectEffective time constantseng
dc.subjectLegendre polynomialseng
dc.subjectSolute concentrationseng
dc.subjectSpherical coordinateseng
dc.subjectControlled drug deliveryeng
dc.titleControlled drug release from a spheroidal matrixeng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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