Evaluación de la actividad antimalárica y citotóxica de estirilquinolinas obtenidas a partir de 8-hidroxiquinaldina con aldehídos aromáticos

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dc.citation.journalTitleInformacion Tecnologicaspa
dc.contributor.authorTorres, O.L.
dc.contributor.authorEspinosa, R.D.
dc.contributor.authorSaez, A.A.
dc.contributor.authorSantafé, G.G.
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupCiencias Biológicas y Bioprocesos (CIBIOP)spa
dc.date.accessioned2021-03-23T20:08:56Z
dc.date.available2021-03-23T20:08:56Z
dc.date.issued2014-01-01
dc.description.abstractThis study reports the synthesis of five (E)-Styrylquinolines (Q.1, Q.2, Q.3, Q.5, Q.6) and three O-alkylated derivatives (Q.1a, Q.6a, Q 6 b) and the evaluation of its antimalarial activity and cytotoxic in vitro. For Styrylquinolines Perkin condensation reaction type from 8-hydroxyquinaldine with aromatic aldehydes was used. Antimalarial activity was performed using the method Radioisotope with FCB-2 strains of Plasmodium falciparum (chloroquine-resistant) and for the cytotoxic activity the MTT method with HepG2 cells was employed. Most compounds showed to be active antimalarial. Those with higher activity were Q.3 (IC50 6.4µM) and Q.5 (IC50 10.8 µM), although all of them were cytotoxic at concentrations above 1 µg / mL. The structures of these compounds were confirmed using infrared spectroscopy techniques and MRI in one and two dimensions. © 2014, Centro de Informacion Tecnologica. All rigths reserved.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1923
dc.identifier.doi10.4067/S0718-07642014000600012spa
dc.identifier.issn07168756spa
dc.identifier.issn07180764spa
dc.identifier.urihttp://hdl.handle.net/10784/26797
dc.language.isospaeng
dc.publisherCentro de Informacion Tecnologica
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84911898065&doi=10.4067%2fS0718-07642014000600012&partnerID=40&md5=031f2faeac070787ba3172604cd5d980
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0716-8756
dc.sourceInformacion Tecnologica
dc.subject.keywordAldehydeseng
dc.subject.keywordAromatic compoundseng
dc.subject.keywordCondensation reactionseng
dc.subject.keywordInfrared spectroscopyeng
dc.subject.keywordSynthesis (chemical)eng
dc.subject.keyword8-Hydroxyquinaldineeng
dc.subject.keywordAntimalarialeng
dc.subject.keywordAntimalarial activityeng
dc.subject.keywordCitotoxicityeng
dc.subject.keywordCytotoxic activitieseng
dc.subject.keywordPerkin reactionseng
dc.subject.keywordPlasmodium falciparumeng
dc.subject.keywordStyrylquinolineseng
dc.subject.keywordCytotoxicityeng
dc.titleEvaluación de la actividad antimalárica y citotóxica de estirilquinolinas obtenidas a partir de 8-hidroxiquinaldina con aldehídos aromáticosspa
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículo

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