Two-dimensional solution and analysis of a cylindrical matrix device with a circular release area

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dc.citation.journalTitleCHEMICAL ENGINEERING COMMUNICATIONS
dc.contributor.authorSimon L.
dc.contributor.authorOspina J.
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon L.
dc.creatorOspina J.
dc.date.accessioned2021-03-26T21:32:05Z
dc.date.available2021-03-26T21:32:05Z
dc.date.issued2013-01-01
dc.description.abstractA cylindrical device was analyzed using a Laplace transform-based method. The two-dimensional model represented a pharmaceutical agent uniformly distributed in a polymeric matrix surrounded by an impermeable layer. Molecules could be transferred only through a small hole centered at the top surface of the cylinder. A closed-form solution was obtained to help study the effects of design parameters and geometries on the cumulative amount of drug released. The latter variable increased with the mass transfer and diffusion coefficients and decreased with any increment in the device's length. The delivery rate was described by an effective time constant calculated from Laplace transforms. Reducing the orifice diameter or fabricating a longer system would delay transport of the medication. Simplified expressions for the release profile and the time constant were derived for special design cases. © 2013 Copyright Taylor and Francis Group, LLC.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7547
dc.identifier.doi10.1080/00986445.2012.695302
dc.identifier.issn00986445
dc.identifier.issn15635201
dc.identifier.otherWOS;000310604500007
dc.identifier.otherSCOPUS;2-s2.0-84867241217
dc.identifier.urihttp://hdl.handle.net/10784/27349
dc.languageeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84867241217&doi=10.1080%2f00986445.2012.695302&partnerID=40&md5=a76b3c72c2213f72822e53c76e89619f
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0098-6445
dc.sourceCHEMICAL ENGINEERING COMMUNICATIONS
dc.subjectCategoricaleng
dc.subjectImputationeng
dc.subjectMissing Valueseng
dc.subjectRough Setseng
dc.titleTwo-dimensional solution and analysis of a cylindrical matrix device with a circular release areaeng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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