Examinando por Materia "Molecular biology"

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    Cloning and expression of the predicted α/β hydrolase enzyme from Variovorax sp. EA-ED0101
    (Universidad EAFIT, 2020) Carmona Berrío, David; Villegas Escobar, Valeska; Correa Álvarez, Javier; Correa Álvarez, Javier; Villegas Escobar, Valeska
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    Ítem
    Evaluation of Antimalarial and Cytotoxic Activity of Styrylquinolines obtained from 8-Hydroxyquinaldine with Aromatic Aldehydes
    (Centro de Información Tecnológica - CIT, 2014) Torres Ayazo, Omar Leonardo; Espinosa Sáez, Roger David; Álex Armando, Sáez Vega; Santafé Patiño, Gilmar Gabriel,; Universidad de Córdoba. Grupo de Investigación Desarrollo de Fármacos y Afines IDEFARMA; Universidad de Córdoba. Grupo de Química de los Productos Naturales; Universidad EAFIT. Departamento de Ciencias; Torres, Omar L. (omart2365@gmail.com); Espinosa, Roger D. (rdespinosa03@gmail.com); Saez, Alex A.(asaez70@gmail.com); Santafé, Gilmar G. ( gsantafe@correo.unicordoba.edu.co); Ciencias Biológicas y Bioprocesos (CIBIOP)
    This study reports the synthesis of five (E)-Styrylquinolines (Q.1, Q.2, Q.3, Q.5, Q.6) and three O-alkylated derivatives (Q.1a, Q.6a, Q 6 b) and the evaluation of its antimalarial activity and cytotoxic in vitro -- For Styrylquinolines Perkin condensation reaction type from 8-hydroxyquinaldine with aromatic aldehydes was used -- Antimalarial activity was performed using the method Radioisotope with FCB-2 strains of Plasmodium falciparum (chloroquine-resistant) and for the cytotoxic activity the MTT method with HepG2 cells was employed -- Most compounds showed to be active antimalarial -- Those with higher activity were Q.3 (IC506.4μM) and Q.5 (IC5010.8 µM), although all of them were cytotoxic at concentrations above 1 µg / mL -- The structures of these compounds were confirmed using infrared spectroscopy techniques and MRI in one and two dimensions