Examinando por Autor "Moreau, Regis"
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Ítem Characteristics of the Rat Cardiac Sphingolipid Pool in Two Mitochondrial Subpopulations(Elsevier Inc., 2010-06-01) Monette, Jeffrey S.; Gómez, Luis A.; Moreau, Regis; Taylor, Alan; Hagen, Tory M.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)Mitochondrial sphingolipids play a diverse role in normal cardiac function and diseases, yet a precise quantification of cardiac mitochondrial sphingolipids has never been performed. Therefore, rat heart interfibrillary mitochondria (IFM) and subsarcolemmÍtem Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age(Elsevier Inc., 2014-07-01) Gómez, Luis A.; Smith, Eric J.; Butler, Judy A.; Moreau, Regis; Hagen, Tory M.; Finlay, Liam A.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults.Ítem (R)-alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria(Elsevier Inc., 2011-01-01) Monette, Jeffrey S.; Gómez, Luis A.; Moreau, Regis; Dunn, Kevin C.; Butler, Judy A.; Finlay, Liam A.; Michels, Alexander J.; Petersen-Shay, Kate; Smith, Eric J.; Hagen, Tory M.; Universidad EAFIT. Departamento de Ciencias; Ciencias Biológicas y Bioprocesos (CIBIOP)Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display many of these characteristics, we hy