Noise and bias in optical coherence tomography intensity signal decorrelation

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dc.citation.journalTitleOsa Continuumeng
dc.contributor.authorUribe-Patarroyo, Nestor
dc.contributor.authorPost, Anouk L.
dc.contributor.authorRuiz-Lopera, Sebastian
dc.contributor.authorFaber, Dirk J.
dc.contributor.authorBouma, Brett E.
dc.contributor.departmentUniversidad EAFIT. Departamento de Ciencias Básicasspa
dc.contributor.researchgroupÓptica Aplicadaspa
dc.date.accessioned2021-04-12T14:18:45Z
dc.date.available2021-04-12T14:18:45Z
dc.date.issued2020-04-15
dc.description.abstractFunctional optical coherence tomography (OCT) imaging based on the decorrelation of the intensity signal has been used extensively in angiography and is finding use in flowmetry and therapy monitoring. In this work, we present a rigorous analysis of the autocorrelation function, introduce the concepts of contrast bias, statistical bias and variability, and identify the optimal definition of the second-order autocorrelation function (ACF) g((2)) to improve its estimation from limited data. We benchmark different averaging strategies in reducing statistical bias and variability. We also developed an analytical correction for the noise contributions to the decorrelation of the ACF in OCT that extends the signal-to-noise ratio range in which ACF analysis can be used. We demonstrate the use of all the tools developed in the experimental determination of the lateral speckle size depth dependence in a rotational endoscopic probe with low NA, and we show the ability to more accurately determine the rotational speed of an endoscopic probe to implement NURD detection. We finally present g((2))-based angiography of the finger nailbed, demonstrating the improved results from noise correction and the optimal bias mitigation strategies. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreementeng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12000
dc.identifier.doi10.1364/OSAC.385431
dc.identifier.issn25787519
dc.identifier.otherWOS;000527275200002
dc.identifier.urihttp://hdl.handle.net/10784/28008
dc.publisherOPTICAL SOC AMER
dc.rightsOPTICAL SOC AMER
dc.sourceOsa Continuum
dc.subject.keywordComplex Differential Varianceeng
dc.subject.keywordSpeckle Decorrelationeng
dc.subject.keywordFlow Measurementeng
dc.subject.keywordScatteringeng
dc.subject.keywordVelocimetryeng
dc.subject.keywordAngiographyeng
dc.subject.keywordResolutioneng
dc.subject.keywordStandardeng
dc.titleNoise and bias in optical coherence tomography intensity signal decorrelationeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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