Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible

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dc.citation.journalTitleJ ORAL MAXIL SURGeng
dc.contributor.authorNagashima, L.K.
dc.contributor.authorRondon-Newby, M.
dc.contributor.authorZakhary, I.E.
dc.contributor.authorNagy, W.W.
dc.contributor.authorZapata, U.
dc.contributor.authorDechow, P.C.
dc.contributor.authorOpperman, L.A.
dc.contributor.authorElsalanty, M.E.
dc.contributor.departmentUniversidad EAFIT. Departamento de Ingeniería Mecánicaspa
dc.contributor.researchgroupBioingeniería GIB (CES – EAFIT)spa
dc.date.accessioned2021-04-12T18:59:07Z
dc.date.available2021-04-12T18:59:07Z
dc.date.issued2012-01-01
dc.description.abstractPurpose: Bone transport distraction osteogenesis provides a promising alternative to traditional grafting techniques. However, existing bone transport distraction osteogenesis devices have many limitations. The purpose of this research was to test a new device, the mandibular bone transport reconstruction plate, in an animal model with comparable mandible size to humans and to histologically and mechanically examine the regenerate bone. Materials and Methods: Eleven adult foxhounds were divided into an unreconstructed control group of 5 animals and an experimental group of 6 animals. In each animal, a 34-mm segmental defect was created in the mandible. The defect was reconstructed with a bone transport reconstruction plate. Histologic and biomechanical characteristics of the regenerate and unrepaired defect were analyzed and compared with bone on the contralateral side of the mandible after 4 weeks of consolidation. Results: The reconstructed defect was bridged with new bone, with little bone in the control defect. Regenerate density and microhardness were 22.3% and 42.6%, respectively, lower than the contralateral normal bone. Likewise, the anisotropy of the experimental group was statistically lower than in the contralateral bone. Half the experimental animals showed nonunion at the docking site. Conclusion: The device was very stable and easy to install and activate. After 1 month of consolidation, the defect was bridged with new bone, with evidence of active bone formation. Regenerate bone was less mature than the control bone. Studies are underway to identify when the regenerate properties compare with normal bone and to identify methods to augment bone union at the docking site. © 2012 American Association of Oral and Maxillofacial Surgeons.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2055
dc.identifier.doi10.1016/j.joms.2011.02.016
dc.identifier.issn2782391
dc.identifier.issn15315053
dc.identifier.otherWOS;000300053900038
dc.identifier.otherPUBMED;21601342
dc.identifier.otherSCOPUS;2-s2.0-84855931931
dc.identifier.urihttp://hdl.handle.net/10784/28148
dc.language.isoeng
dc.publisherW.B. Saunders Ltd
dc.relationDOI;10.1016/j.joms.2011.02.016
dc.relationWOS;000300053900038
dc.relationPUBMED;21601342
dc.relationSCOPUS;2-s2.0-84855931931
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84855931931&doi=10.1016%2fj.joms.2011.02.016&partnerID=40&md5=6750ad2ab639598efe8e846111c1815d
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0278-2391
dc.sourceJ ORAL MAXIL SURG
dc.subjectanimal experimenteng
dc.subjectanimal modeleng
dc.subjectanimal tissueeng
dc.subjectarticleeng
dc.subjectbiomechanicseng
dc.subjectboneeng
dc.subjectbone regenerationeng
dc.subjectbone transport reconstruction plateeng
dc.subjectcontrolled studyeng
dc.subjectdeviceseng
dc.subjectdistraction osteogenesiseng
dc.subjectdogeng
dc.subjecthistologyeng
dc.subjectmandibleeng
dc.subjectnonhumaneng
dc.subjectultrasoundeng
dc.subjectAnimalseng
dc.subjectAnisotropyeng
dc.subjectBiomechanicseng
dc.subjectBone Densityeng
dc.subjectBone Plateseng
dc.subjectBone Regenerationeng
dc.subjectBone Screwseng
dc.subjectColoring Agentseng
dc.subjectDogseng
dc.subjectElastic Moduluseng
dc.subjectEquipment Designeng
dc.subjectHardnesseng
dc.subjectMandibleeng
dc.subjectModelseng
dc.subjectAnimaleng
dc.subjectOsteogenesiseng
dc.subjectOsteogenesiseng
dc.subjectDistractioneng
dc.subjectOsteotomyeng
dc.subjectRosaniline Dyeseng
dc.subjectWound Healingeng
dc.titleBone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandibleeng
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeinfo:eu-repo/semantics/articleeng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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