The development of a peak-time criterion for designing controlled-release devices

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dc.citation.journalTitleEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.contributor.authorSimon, L.
dc.contributor.authorOspina, J.
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon, L.
dc.creatorOspina, J.
dc.date.accessioned2021-03-26T21:32:05Z
dc.date.available2021-03-26T21:32:05Z
dc.date.issued2016-08-25
dc.description.abstractThis work consists of estimating dynamic characteristics for topically-applied drugs when the magnitude of the flux increases to a maximum value, called peak flux, before declining to zero. This situation is typical of controlled- released systems with a finite donor or vehicle volume. Laplace transforms were applied to the governing equations and resulted in an expression for the flux in terms of the physical characteristics of the system. After approximating this function by a second-order model, three parameters of this reduced structure captured the essential features of the original process. Closed-form relationships were then developed for the peak flux and time-to-peak based on the empirical representation. Three case studies that involve mechanisms, such as diffusion, partitioning, dissolution and elimination, were selected to illustrate the procedure. The technique performed successfully as shown by the ability of the second-order flux to match the prediction of the original transport equations. A main advantage of the proposed method is that it does not require a solution of the original partial differential equations. Less accurate results were noted for longer lag times. (C) 2016 Elsevier B.V. All rights reserved.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3689
dc.identifier.doi10.1016/j.ejps.2016.05.028
dc.identifier.issn09280987
dc.identifier.issn18790720
dc.identifier.otherWOS;000382532100008
dc.identifier.otherPUBMED;27260085
dc.identifier.otherSCOPUS;2-s2.0-84973547642
dc.identifier.urihttp://hdl.handle.net/10784/27342
dc.languageeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84973547642&doi=10.1016%2fj.ejps.2016.05.028&partnerID=40&md5=b83e9d66661072d56aac9b7c81347c37
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0928-0987
dc.sourceEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.subjectMathematical modelseng
dc.subjectDiffusioneng
dc.subjectControlled releaseeng
dc.subjectPeak timeeng
dc.titleThe development of a peak-time criterion for designing controlled-release deviceseng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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