Dynamic analysis and performance evaluation of the BIAcore surface plasmon resonance biosensor

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dc.contributor.authorSimon, Laurent
dc.contributor.authorOspina, Juan
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon, Laurent
dc.creatorOspina, Juan
dc.date.accessioned2021-03-26T21:35:20Z
dc.date.available2021-03-26T21:35:20Z
dc.date.issued2015-01-01
dc.description.abstractSolution procedures were proposed to analyze nonlinear mass transport through an optical biosensor. A generalized collocation technique was applied to predict the dynamic behavior of an analyte along the flow chamber as a result of convection, diffusion and chemical reaction. The method estimated the effective time constants for reaching average steady-state concentrations of the free and bound analytes in the cell. When diffusion in the direction of flow was neglected, a closed-form solution, based on double Laplace transforms, was obtained after linearizing the original system. In both models, an increase in the sample diffusion coefficient lowered the effective time constant. This approach may help researchers evaluate the performance of biosensors and meet specific design criteria. © 2015 SPIE.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2246
dc.identifier.doi10.1117/12.2177807
dc.identifier.issn0277786X
dc.identifier.issn1996756X
dc.identifier.otherWOS;000359469900004
dc.identifier.otherSCOPUS;2-s2.0-84948743223
dc.identifier.urihttp://hdl.handle.net/10784/27413
dc.language.isoengeng
dc.publisherSPIE-INT SOC OPTICAL ENGINEERING
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84948743223&doi=10.1117%2f12.2177807&partnerID=40&md5=055b2784d09c9a606f9ecc0e953435f0
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0277-786X
dc.sourceProceedings of SPIE
dc.subject.keywordBiosensorseng
dc.subject.keywordChemical analysiseng
dc.subject.keywordDiffusioneng
dc.subject.keywordDynamic analysiseng
dc.subject.keywordPhysiologyeng
dc.subject.keywordSurface plasmon resonanceeng
dc.subject.keywordClosed form solutionseng
dc.subject.keywordCollocationeng
dc.subject.keywordCollocation techniqueseng
dc.subject.keywordDouble Laplace transformeng
dc.subject.keywordEffective time constantseng
dc.subject.keywordOptical bio-sensorseng
dc.subject.keywordSteady state concentrationeng
dc.subject.keywordSurface plasmon resonance biosensoreng
dc.subject.keywordLaplace transformseng
dc.titleDynamic analysis and performance evaluation of the BIAcore surface plasmon resonance biosensoreng
dc.typeinfo:eu-repo/semantics/conferencePapereng
dc.typeconferencePapereng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localDocumento de conferenciaspa

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