Two-dimensional transport analysis of transdermal drug absorption with a non-perfect sink boundary condition at the skin-capillary interface

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dc.citation.journalTitleMATHEMATICAL BIOSCIENCES
dc.contributor.authorSimon, Laurent
dc.contributor.authorOspina, Juan
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon, Laurent
dc.creatorOspina, Juan
dc.date.accessioned2021-03-26T21:32:04Z
dc.date.available2021-03-26T21:32:04Z
dc.date.issued2013-07-01
dc.description.abstractA transient percutaneous drug absorption model was solved in two dimensions. Clearance of the topically-applied pharmaceutical occured at the skin-capillary boundary. Timolol penetration profiles in the dermal tissue were produced revealing concentration gradients in the directions normal and parallel to the skin surface. Ninety-eight percent of the steady-state flux was reached after 85. h or four time constants. The analytical solution procedure agreed with published results. As the clearance rate increased relative to diffusion, the delivery rate and amount of drug absorbed into the bloodstream increased while the time to reach the equilibrium flux decreased. Researchers can apply the closed-form expressions to simulate the process, estimate key parameters and design devices that meet specific performance requirements. © 2013 Elsevier Inc.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1561
dc.identifier.doi10.1016/j.mbs.2013.04.004
dc.identifier.issn00255564
dc.identifier.issn18793134
dc.identifier.otherWOS;000320747800007
dc.identifier.otherPUBMED;23624255
dc.identifier.otherSCOPUS;2-s2.0-84878458631
dc.identifier.urihttp://hdl.handle.net/10784/27331
dc.languageeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84878458631&doi=10.1016%2fj.mbs.2013.04.004&partnerID=40&md5=2dfbe5dc61c0f65ec156f760e91ffb58
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0025-5564
dc.sourceMATHEMATICAL BIOSCIENCES
dc.subjectClosed-form expressioneng
dc.subjectConcentration gradientseng
dc.subjectPenetration profileseng
dc.subjectPercutaneous absorptioneng
dc.subjectPercutaneous drug absorptioneng
dc.subjectPerformance requirementseng
dc.subjectSolution procedureeng
dc.subjectTime constantseng
dc.subjectLaplace transformseng
dc.subjectPartial differential equationseng
dc.subjectTissueeng
dc.subjectTwo dimensionaleng
dc.subjecttimololeng
dc.subjectabsorptioneng
dc.subjectbloodeng
dc.subjectboundary conditioneng
dc.subjectdiffusioneng
dc.subjectdrugeng
dc.subjectequationeng
dc.subjectLaplace transformeng
dc.subjectskineng
dc.subjectarticleeng
dc.subjectblood floweng
dc.subjectcapillaryeng
dc.subjectconcentration (parameters)eng
dc.subjectcontrolled studyeng
dc.subjectdrug absorptioneng
dc.subjectdrug clearanceeng
dc.subjectdrug delivery systemeng
dc.subjectdrug diffusioneng
dc.subjectdrug transporteng
dc.subjectequipment designeng
dc.subjectmathematical modeleng
dc.subjectperformanceeng
dc.subjectskineng
dc.subjectsteady stateeng
dc.subjecttransdermal drug administrationeng
dc.subjectAdministration, Cutaneouseng
dc.subjectCapillarieseng
dc.subjectModels, Biologicaleng
dc.subjectSkineng
dc.subjectSkin Absorptioneng
dc.subjectTimololeng
dc.titleTwo-dimensional transport analysis of transdermal drug absorption with a non-perfect sink boundary condition at the skin-capillary interfaceeng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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