On the effusion time of drugs from the open pore of a spherical vesicle

Vista sencilla de ítem
dc.citation.journalTitlePHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
dc.contributor.authorSimon, L.
dc.contributor.authorOspina, J.
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon, L.
dc.creatorOspina, J.
dc.date.accessioned2021-03-26T21:32:04Z
dc.date.available2021-03-26T21:32:04Z
dc.date.issued2016-06-01
dc.description.abstractSolute permeation through a spherical liposomal vesicle was analyzed using Fick's second law and a mixed Neumann-Dirichlet boundary condition. The first-principles approach was necessary to help calculate the effusion time of a medication through a pore located on the surface of the device. An infinite series of Bessel functions represented the concentration in the Laplace domain. This method yielded closed-form expressions for the characteristic time and the Laplace-transformed fraction of drug released, which was approximated by the first term of the series. The time constant was inversely proportional to the diffusion coefficient in the system and decreased as the pore size increased. It took 4 times the effusion time to unload nearly ninety-eight percent of the pharmaceutical ingredient. (C) 2016 Elsevier B.V. All rights reserved.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2159
dc.identifier.doi10.1016/j.physa.2016.01.097
dc.identifier.issn03784371
dc.identifier.issn18732119
dc.identifier.otherWOS;000373420800034
dc.identifier.otherSCOPUS;2-s2.0-84959020322
dc.identifier.urihttp://hdl.handle.net/10784/27340
dc.languageeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84959020322&doi=10.1016%2fj.physa.2016.01.097&partnerID=40&md5=47ca1ef1101c760a32be2ed7d5514e64
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0378-4371
dc.sourcePHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
dc.subjectEffusion timeeng
dc.subjectEffective time constanteng
dc.subjectControlled releaseeng
dc.subjectSpherical deviceeng
dc.subjectLaplace transformeng
dc.subjectBessel functioneng
dc.titleOn the effusion time of drugs from the open pore of a spherical vesicleeng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
1-s2.0-S0378437116001618-main.pdf
Tamaño:
519.56 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar

Colecciones

Artículos