GABAA receptors (aminobutyric acid) and their relationship to alcohol dependence
| dc.citation.epage | 96 | |
| dc.citation.issue | 1 | |
| dc.citation.journalAbbreviatedTitle | ing.cienc. | eng |
| dc.citation.journalTitle | Ingeniería y Ciencia | eng |
| dc.citation.spage | 77 | |
| dc.citation.volume | 1 | |
| dc.contributor.affiliation | Inelpres, Colombia. | spa |
| dc.contributor.affiliation | Universidad Distrital Francisco José de Caldas, Colombia. | spa |
| dc.contributor.affiliation | Universidad Nacional de Colombia | spa |
| dc.contributor.author | Rengifo, Aura | spa |
| dc.contributor.author | Tapiero, Carolina | spa |
| dc.contributor.author | Spinel, Clara | spa |
| dc.coverage.spatial | Medellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees | eng |
| dc.date | 2005-04-01 | |
| dc.date.accessioned | 2019-11-22T19:22:15Z | |
| dc.date.available | 2019-11-22T19:22:15Z | |
| dc.date.issued | 2005-04-01 | |
| dc.description | Alcohol dependence syndrome is a multifactorial, environmental, cultural, social and genetic disease. There are innumerable investigations that have attempted to elude the possible neurobiological mechanisms of this syndrome to understand the physiological and behavioral changes of the individual, so that pharmacological alternatives can be provided that help control this type of dependence. This review describes the role of neurotransmission involved in alcohol dependence syndrome, mainly related to glutamate, dopamine, opioids and especially γ-aminobutyric acid (GABA), because the activation of the GABAA receptor ( Chlorine channel receptor) triggers an inhibitory effect at the neuronal level, and in alcoholic individuals it presents hypofunction, which does not allow it to modulate the recurrent neuronal excitation resulting in a state of disinhibition / hyperexcitation typical of alcoholics. On the other hand, the genes that code for the GABAA receptor subunits located on chromosomes 4 and 15 have been associated with alcoholism, as there are strong relationships between the binding imbalance between these genes and the phenotype of β waves in electroencephalograms of individuals with alcohol dependence syndrome and their descendants. | eng |
| dc.description | El síndrome de dependencia al alcohol es una enfermedad multifactorial, ambiental, cultural, social y genética. Son innumerables las investigaciones que han intentado elu- cidar los posibles mecanismos neurobiológicos de este síndrome para entender los cambios fisiológicos y comportamentales del individuo, de tal manera que se puedan brindar alter- nativas farmacológicas que ayuden a controlar este tipo dependencia. Esta revisión describe el papel de la neurotransmisión involucrada en el síndrome de de- pendencia al alcohol, principalmente la relacionada con el glutamato, la dopamina, los opioides y en especial el ácido γ-aminobutírico (GABA), porque la activación del receptor GABAA (receptor canal de cloro) desencadena un efecto inhibitorio a nivel neuronal, y en individuos alcohólicos presenta hipofunción, la cual no le permite modular la recurrente excitación neuronal obteniendo como resultado un estado de desinhibición/hiperexcitación típico de alcohólicos. Por otra parte, los genes que codifican para las subunidades de los receptores GABAA ubicados en los cromosomas 4 y 15 han sido asociados con alcoholismo, al presentarse fuertes relaciones entre el desequilibrio de unión entre estos genes y el fenotipo de las ondas β en los electroencefalogramas de los individuos con el síndrome de dependencia al alcohol y sus descendientes. | spa |
| dc.format | application/pdf | |
| dc.identifier.issn | 2256-4314 | |
| dc.identifier.issn | 1794-9165 | |
| dc.identifier.uri | http://hdl.handle.net/10784/14580 | |
| dc.language.iso | spa | spa |
| dc.publisher | Universidad EAFIT | spa |
| dc.relation.isversionof | http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/505 | |
| dc.relation.uri | http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/505 | |
| dc.rights | Copyright (c) 2005 Aura Rengifo, Carolina Tapiero, Clara Spinel | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | eng |
| dc.rights.local | Acceso abierto | spa |
| dc.source | instname:Universidad EAFIT | |
| dc.source | reponame:Repositorio Institucional Universidad EAFIT | |
| dc.source | Ingeniería y Ciencia; Vol 1, No 1 (2005) | spa |
| dc.subject.keyword | Alcohol Dependence Syndrome | eng |
| dc.subject.keyword | Alcohol Withdrawal Syndrome | eng |
| dc.subject.keyword | Reinforcement | eng |
| dc.subject.keyword | Reward | eng |
| dc.subject.keyword | Inhibition | eng |
| dc.subject.keyword | Hyperexcitation | eng |
| dc.subject.keyword | Síndrome De Dependencia Al Alcohol | spa |
| dc.subject.keyword | Síndrome De Abstinencia Al Alcohol | spa |
| dc.subject.keyword | Reforzamiento | spa |
| dc.subject.keyword | Recompensa | spa |
| dc.subject.keyword | Inhibición | spa |
| dc.subject.keyword | Hiperexcitación | spa |
| dc.title | GABAA receptors (aminobutyric acid) and their relationship to alcohol dependence | eng |
| dc.title | Receptores GABAA (ácido γ-aminobutírico) y su relación con la dependencia al alcohol | spa |
| dc.type | article | eng |
| dc.type | info:eu-repo/semantics/article | eng |
| dc.type | publishedVersion | eng |
| dc.type | info:eu-repo/semantics/publishedVersion | eng |
| dc.type.local | Artículo | spa |