Two-dimensional description of absorption in humans after dermal exposure to volatile organic compounds

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dc.citation.journalTitleCHEMICAL ENGINEERING COMMUNICATIONS
dc.contributor.authorSimon, Laurent
dc.contributor.authorOspina, Juan
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon, Laurent
dc.creatorOspina, Juan
dc.date.accessioned2021-03-26T21:32:05Z
dc.date.available2021-03-26T21:32:05Z
dc.date.issued2017-06-03
dc.description.abstractA two-dimensional diffusion model was developed to predict the absorption of chemicals in humans following dermal contact. A firstorder evaporation rate equation was applied to the skin surface while a perfect-sink boundary condition was imposed at the stratum corneum/viable epidermis interface. Initially, there was a certain amount of the substance present within the stratum corneum at the end of the exposure period. Laplace transform techniques were implemented to solve the governing equations and to derive an expression for the time elapsed before reaching 90% of the final amount of chemical absorbed by the body. This index was 0.43, 2.67, 6.91, and 36.9 h for ethanol, diphenylamine, p-nitroaniline, and benzyl butyl-phthalate, respectively. Simulations show that surface evaporation is important for highly volatile compounds. A large fraction of the amount of poorly volatile compounds, available in the skin after exposure, was absorbed into the bloodstream. © Taylor & Francis Group, LLC.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6917
dc.identifier.doi10.1080/00986445.2017.1306519
dc.identifier.issn00986445
dc.identifier.issn15635201
dc.identifier.otherWOS;000404269100007
dc.identifier.otherSCOPUS;2-s2.0-85034598594
dc.identifier.urihttp://hdl.handle.net/10784/27347
dc.languageeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85034598594&doi=10.1080%2f00986445.2017.1306519&partnerID=40&md5=9dfb3f7d735e958c5b5e07403691530c
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0098-6445
dc.sourceCHEMICAL ENGINEERING COMMUNICATIONS
dc.subjectClosed form solutionseng
dc.subjectControlled releaseeng
dc.subjectCumulative amounteng
dc.subjectCylindrical matriceseng
dc.subjectDesign parameterseng
dc.subjectEffective timeeng
dc.subjectOrifice diameterseng
dc.subjectPharmaceutical agentseng
dc.subjectPolymeric matriceseng
dc.subjectRelease profileseng
dc.subjectSimplified expressionseng
dc.subjectSimulationeng
dc.subjectSmall Holeeng
dc.subjectTime constantseng
dc.subjectTop surfaceeng
dc.subjectTransfer and diffusion coefficientseng
dc.subjectTransform-based methodseng
dc.subjectTransport phenomenaeng
dc.subjectTwo dimensional modeleng
dc.subjectTwo-dimensional solutionseng
dc.subjectDiffusioneng
dc.subjectDrug deliveryeng
dc.subjectMathematical modelseng
dc.subjectTwo dimensionaleng
dc.subjectLaplace transformseng
dc.titleTwo-dimensional description of absorption in humans after dermal exposure to volatile organic compoundseng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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