Prediction of in-vivo iontophoretic drug release data from in-vitro experiments-insights from modeling

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dc.citation.journalTitleMATHEMATICAL BIOSCIENCES
dc.contributor.authorSimon, L.
dc.contributor.authorOspina, J.
dc.contributor.authorIta, K.
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon, L.
dc.creatorOspina, J.
dc.creatorIta, K.
dc.date.accessioned2021-03-26T21:32:04Z
dc.date.available2021-03-26T21:32:04Z
dc.date.issued2015-12-01
dc.description.abstractA strategy was developed to predict in-vivo plasma drug levels from data collected during in-vitro transdermal iontophoretic delivery experiments. The method used the principle of mass conservation and the Nernst-Planck flux equation to describe molecular transport across the skin. Distribution and elimination of the drug in the body followed a one- or two-compartment open model. Analytical expressions for the relaxation constant and plasma drug concentration were developed using Laplace transforms. The steady-state dermal flux was appropriate for predicting drug absorption under in-vivo conditions only when the time constant in the skin was far greater than its value in the blood compartment. A simulation study was conducted to fully assess the performance of estimations based on the equilibrium flux approximation. The findings showed that the normalized integral of squared error decreased exponentially as the ratio of the two time constants (blood/skin) increased. In the case of a single compartment, the error was reduced from 0.15 to 0.016 when the ratio increased from 10 to 100. The methodology was tested using plasma concentrations of a growth-hormone releasing factor in guinea pigs and naloxone in rats. © 2015 Elsevier Inc. All rights reserved.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1791
dc.identifier.doi10.1016/j.mbs.2015.10.011
dc.identifier.issn00255564
dc.identifier.issn18793134
dc.identifier.otherWOS;000367771000010
dc.identifier.otherPUBMED;26519787
dc.identifier.otherSCOPUS;2-s2.0-84947592132
dc.identifier.urihttp://hdl.handle.net/10784/27332
dc.languageeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84947592132&doi=10.1016%2fj.mbs.2015.10.011&partnerID=40&md5=295bf6d35940dde4400172817059d67f
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0025-5564
dc.sourceMATHEMATICAL BIOSCIENCES
dc.subjectIontophoresiseng
dc.subjectIn-vivo in-vitro correlationeng
dc.subjectLaplace transformeng
dc.subjectControlled releaseeng
dc.subjectClosed-form solutioneng
dc.titlePrediction of in-vivo iontophoretic drug release data from in-vitro experiments-insights from modelingeng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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