Three-dimensional analyses of a perforated cylindrical drug delivery device

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dc.citation.journalTitleINTERNATIONAL JOURNAL OF PHARMACEUTICS
dc.contributor.authorSimon L
dc.contributor.authorOspina J
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon L
dc.creatorOspina J
dc.date.accessioned2021-03-26T21:32:03Z
dc.date.available2021-03-26T21:32:03Z
dc.date.issued2015-03-15
dc.description.abstractA closed-formed solution of a perforated drug-delivery model was developed. Laplace transforms were applied to the governing equation, which included diffusion through the tubular device and mass transfer across a rectangular cut. A first-order estimate for the fraction of drug released, in terms of the Laplace variable, was derived after employing suitable boundary and initial conditions. The effective time constant for the process was calculated. The residue theorem and the Zakian method were proposed as two reliable approaches to recover the solution in the time domain. Simulations show that the drug was released faster at higher Sherwood numbers. Ninety-eight percent (98%) of the loading dose was delivered after a period corresponding to four time constants. This analytical platform can aid in the design of implants for long-term delivery applications. (C) 2015 Elsevier B.V. All rights reserved.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1543
dc.identifier.doi10.1016/j.ijpharm.2015.01.047
dc.identifier.issn03785173
dc.identifier.issn18733476
dc.identifier.otherWOS;000350453600008
dc.identifier.otherPUBMED;25637879
dc.identifier.otherSCOPUS;2-s2.0-84922347962
dc.identifier.urihttp://hdl.handle.net/10784/27329
dc.languageeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84922347962&doi=10.1016%2fj.ijpharm.2015.01.047&partnerID=40&md5=259d9f6400fa6d0a5a03cbdf6df5c141
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0378-5173
dc.sourceINTERNATIONAL JOURNAL OF PHARMACEUTICS
dc.subjectThree-dimensional modeleng
dc.subjectEffective time constanteng
dc.subjectCylindrical deviceeng
dc.subjectResidue theoremeng
dc.subjectControlled releaseeng
dc.titleThree-dimensional analyses of a perforated cylindrical drug delivery deviceeng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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