The dynamics of shrinking and expanding drug-loaded microspheres: A semi-empirical approach

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dc.citation.journalTitleEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.contributor.authorSimon L
dc.contributor.authorOspina J
dc.contributor.authorWillits RK
dc.contributor.departmentUniversidad EAFIT. Departamento de Cienciasspa
dc.contributor.researchgroupLógica y Computaciónspa
dc.creatorSimon L
dc.creatorOspina J
dc.creatorWillits RK
dc.date.accessioned2021-03-26T21:32:03Z
dc.date.available2021-03-26T21:32:03Z
dc.date.issued2014-07-16
dc.description.abstractThe dynamics of shrinking and expanding drug-loaded microspheres were studied using a diffusion equation in spherical coordinates. A movable boundary condition was incorporated as a convection term in the original model. The resulting convective-diffusive problem was solved using Laplace transform techniques with the Bromwich integral and the residue theorem. Analytical solutions were derived for the general case of shrinking or expanding microspheres and three particular kinetics expressions: linear growth, exponential swelling and exponential shrinking. Simulations show that microspheres with fast-swelling kinetics released their therapeutic cargo at a relatively slow rate in the first two cases. Ninety-nine percent of the medication was delivered at four times the effective time constant. In line with laboratory studies using bovine serum albumin, an increase in the shrinking rate led to a fast release of the medication from its carrier. The method was applied to analyze insulin transport through spherical Ca-alginate beads. A good agreement was noted between predicted and experimental data. The theoretical effective time constant was 114.0 min.eng
dc.identifierhttps://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1542
dc.identifier.doi10.1016/j.ejps.2014.03.005
dc.identifier.issn09280987
dc.identifier.issn18790720
dc.identifier.otherWOS;000336828800007
dc.identifier.otherPUBMED;24681260
dc.identifier.otherSCOPUS;2-s2.0-84899456884
dc.identifier.urihttp://hdl.handle.net/10784/27328
dc.languageeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84899456884&doi=10.1016%2fj.ejps.2014.03.005&partnerID=40&md5=b836b1b049638b430879852156ff7694
dc.rightshttps://v2.sherpa.ac.uk/id/publication/issn/0928-0987
dc.sourceEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.subjectAnalytical solutioneng
dc.subjectControlled releaseeng
dc.subjectEffective time constanteng
dc.subjectHydrogelseng
dc.subjectPolymeric drug delivery systemseng
dc.subjectSwelling/shrinking microsphereseng
dc.titleThe dynamics of shrinking and expanding drug-loaded microspheres: A semi-empirical approacheng
dc.typearticleeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.typepublishedVersioneng
dc.type.localArtículospa

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