Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring
| dc.citation.epage | 144 | |
| dc.citation.issue | 4 | |
| dc.citation.journalAbbreviatedTitle | ing.cienc. | eng |
| dc.citation.journalTitle | Ingeniería y Ciencia | eng |
| dc.citation.spage | 125 | |
| dc.citation.volume | 2 | |
| dc.contributor.affiliation | Universidad Juárez Autónoma de Tabasco | spa |
| dc.contributor.author | Alavez-Ramírez, Justino | spa |
| dc.coverage.spatial | Medellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees | eng |
| dc.date | 2006-12-01 | |
| dc.date.accessioned | 2019-11-22T19:18:48Z | |
| dc.date.available | 2019-11-22T19:18:48Z | |
| dc.date.issued | 2006-12-01 | |
| dc.description | The reduced standard model of three populations (healthy and diseased hepatocytes, and viral load) for the study of hepatitis C virus (HCV) dynamics is compared with the model of viral dynamics with alanine aminotransferase (ALT). In terms of the threshold parameter that is the same for both models, the existence and stability of the endemic equilibrium state is determined, as well as the overall stability of the healthy individual's equilibrium state. On the other hand, an experimental study is presented that shows that it is possible to monitor liver damage without biopsies, by numerical estimation of the model parameters, considering only measurements of viral load, ALT levels and a reasonable assessment of liver damage pretreatment. | eng |
| dc.description | Se compara el modelo estándar reducido de tres poblaciones (hepatocitos sanos y enfermos, y carga viral) para el estudio de la dinámica del virus de la hepatitis C (VHC), con el modelo de la dinámica viral con alanina aminotransferasa (ALT). En términos del parámetro umbral que es el mismo para ambos modelos, se determina la existencia y estabilidad del estado de equilibrio endémico, así como la estabilidad global del estado de equilibrio del individuo sano. Por otro lado, se presenta un estudio experimental que muestra que es posible monitorear el daño hepático sin biopsias, mediante la estimación numérica de los parámetros de los modelos, considerando solamente mediciones de la carga viral, de los niveles de ALT y una valoración razonable del daño hepático pretratamiento.a | spa |
| dc.format | application/pdf | |
| dc.identifier.issn | 2256-4314 | |
| dc.identifier.issn | 1794-9165 | |
| dc.identifier.uri | http://hdl.handle.net/10784/14556 | |
| dc.language.iso | spa | spa |
| dc.publisher | Universidad EAFIT | spa |
| dc.relation.isversionof | http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/472 | |
| dc.relation.uri | http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/472 | |
| dc.rights | Copyright (c) 2006 Justino Alavez-Ramírez | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | eng |
| dc.rights.local | Acceso abierto | spa |
| dc.source | instname:Universidad EAFIT | |
| dc.source | reponame:Repositorio Institucional Universidad EAFIT | |
| dc.source | Ingeniería y Ciencia; Vol 2, No 4 (2006) | spa |
| dc.subject.keyword | Hepatitis C | eng |
| dc.subject.keyword | Viral Load | eng |
| dc.subject.keyword | Liver Damage | eng |
| dc.subject.keyword | Biopsies | eng |
| dc.subject.keyword | Parameters | eng |
| dc.subject.keyword | Threshold Parameter | eng |
| dc.subject.keyword | Hepatitis C | spa |
| dc.subject.keyword | Carga Viral | spa |
| dc.subject.keyword | Daño Hepático | spa |
| dc.subject.keyword | Biopsias | spa |
| dc.subject.keyword | Parámetros | spa |
| dc.subject.keyword | Parámetro Umbral | spa |
| dc.title | Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring | eng |
| dc.title | Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias | spa |
| dc.type | article | eng |
| dc.type | info:eu-repo/semantics/article | eng |
| dc.type | publishedVersion | eng |
| dc.type | info:eu-repo/semantics/publishedVersion | eng |
| dc.type.local | Artículo | spa |