Inferring tumor age from multiple neutral evolutionary process

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dc.contributor.advisorPulido Tamayo, Sergiospa
dc.contributor.authorLondoño Muñoz, Susana
dc.coverage.spatialMedellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degreeseng
dc.creator.degreeBiólogo(a)spa
dc.creator.emailslondo50@eafit.edu.cospa
dc.date.accessioned2019-11-29T16:54:55Z
dc.date.available2019-11-29T16:54:55Z
dc.date.issued2019
dc.description.abstractBackground: All cancer arise as a result of a somatic mutation, several models have been developed to understand cancer, it has been seen as an evolutionary process in which somatic mutations are the pieces of the puzzle. Somatic mutation catalogue of the cancer genome has been used to reconstruct cancer phylogeny, in this case somatic mutations without selective pressure will help determine the age of a tumor. Results: Any type of mutation can have an impact on the cell, the majority of them are neutral, mutations that have less functional impact, that means less selective pressure on the tumor evolution are the ones used as temporal measurement of the tumors. A positive correlation was found between two types of measurements, which shows that an appropriate age can be extracted using both of them. Conclusion: The use of this method can be coupled with other cancer analysis, for example, along with co-occurrence and mutual exclusivity analysis could bring a better understanding of the tumor, an appropriate tumor classification and with this a more accurate clinical decision, which leads to an efective treatment.spa
dc.formatapplication/pdfeng
dc.identifier.ddc616.994 L864
dc.identifier.urihttp://hdl.handle.net/10784/14908
dc.language.isospaspa
dc.publisherUniversidad EAFITspa
dc.publisher.departmentEscuela de Ciencias. Ciencias Básicasspa
dc.publisher.placeMedellínspa
dc.publisher.programBiologíaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.localAcceso abiertospa
dc.subjectProceso evolutivo neutral múltiplespa
dc.subjectTumorspa
dc.subjectCáncerspa
dc.subjectMutaciones somáticasspa
dc.subjectEdad del tumorspa
dc.subject.keywordTumorspa
dc.subject.keywordMultiple neutral evolutionary processspa
dc.subject.keywordCancerspa
dc.subject.keywordSomatic mutationsspa
dc.subject.keywordTumor agespa
dc.subject.lembPATOLOGÍA MOLECULARspa
dc.subject.lembCÁNCER - ASPECTOS MOLECULARESspa
dc.subject.lembNEOPLASMASspa
dc.subject.lembDIVERSIDAD DE ANTICUERPOSspa
dc.titleInferring tumor age from multiple neutral evolutionary processspa
dc.typeinfo:eu-repo/semantics/bachelorThesiseng
dc.typebachelorThesiseng
dc.type.hasVersionacceptedVersioneng
dc.type.localTrabajo de gradospa

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Biología (trabajo de grado)