Computational Study of Cell Mobility and Transport Phenomena Through Textile Vascular Grafts Using a Multi-Scale Approach

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dc.contributor.advisorGarcía Ruíz, Manuel Julio
dc.contributor.advisorBustamante Osorno, John
dc.contributor.authorValencia Cardona, Raúl Adolfo
dc.coverage.spatialMedellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degreeseng
dc.creator.degreeDoctor in Engineeringspa
dc.creator.emailrvalenc2@eafit.edu.cospa
dc.date.accessioned2017-06-21T15:21:46Z
dc.date.available2017-06-21T15:21:46Z
dc.date.issued2015
dc.description.abstractTextile vascular grafts are biomedical devices that serve as partial replacement of damaged arterial vessels, prevent aneurysms rupture and restore normal blood flow -- It is believed that the success of a textile vascular graft, in the healing process after implantation, is due to the porous micro-structure of the wall -- Among the key properties that take part in the tissue repair process are the type of fabric and degree of porosity and permeability, defining the ability of a well-controlled environment for the neovascularization, nutrient supply, and cellular transport -- Although the transport of fluids through textiles is of great technical interest in biomedical applications, little is known about predicting the micro-flow pattern and the transport and deposition of individual platelets, related with the graft occlusion -- Often, this information is difficult to obtain experimentally both in vivo and in vitro, representing a great deal of research efforts -- The aim of this work is to investigate how the type of fabric, permeability and porosity affect both the local fluid dynamics at several scales and the fluid-particle interaction among platelets in textile grafts with an anastomosis of end-to-end configuration -- Two types of samples were analyzed: woven and electrospun, this last one has been manufactured -- This study involves both experimental and computational tests -- The experimental tests were performed to characterize the permeability and porosity under static conditions -- The computational tests are based on a multiscale approach where the fluid flow was solved with the Finite Element Method and the discrete particles were solved with the Molecular Dynamic Method -- The fluid-particle interaction was accomplished in one-, two-, and four-ways, where the blood was considered as a suspension of platelets in plasma -- The textile wall was considered as a porous media with two scales of length: straight tubular structure with porous walls for the macro-domain and representative unit cells of fabric for the micro-domain. Additionally, it presents the implementation of a numerical case that includes one of the main applications of textile vascular grafts to repair Abdominal Aortic Aneurysms (AAA) -- The results have shown that the type of fabric in textile vascular grafts and the degree of porosity and permeability affect the local fluid dynamics and the level of penetration of platelet particles through the graft wall at several length scales, thus indicating their importance as design parameters -- It was found that the permeability is strongly depends on the micro-structure of the fabric, changing the local fluid dynamics and the time of residence of platelets inside the wall -- Moreover, the porous walls cause deviations from Poiseuille flow due to leakage flow through the wall from a macroscopic viewpoint -- Lastly, it was possible to observe that the textile wall with different porosities, acting like a barrier between the blood and an aneurysmal zone, affects the flow pattern, the number of platelets adhered to the artificial surface and the time of residence of platelets into the aneurysmal zone -- In conclusion, predicting the flow pattern and the mobility of blood cells through the textile wall before the graft is manufactured, the development of new textile grafts can be improvedspa
dc.identifier.local660.2842CD V152C
dc.identifier.urihttp://hdl.handle.net/10784/11482
dc.language.isospaspa
dc.publisherUniversidad EAFITspa
dc.publisher.departmentEscuela de Ingenieríaspa
dc.publisher.programDoctorado en Ingenieríaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.localAcceso abiertospa
dc.subjectMedicina regenerativaspa
dc.subjectIngeniería de tejidosspa
dc.subjectAngiografía por resonancia magnéticaspa
dc.subjectDinámica de Fluídos Computacionales (CFD)spa
dc.subject.keywordFinite element methodspa
dc.subject.keywordArteriovenous anastomosisspa
dc.subject.keywordBlood-vessels prosthesisspa
dc.subject.keywordAneurysmsspa
dc.subject.keywordBiomedical materialsspa
dc.subject.keywordPolymers in medicinespa
dc.subject.keywordTissues - Preservationspa
dc.subject.keywordFluid dynamicsspa
dc.subject.keywordPorous materialsspa
dc.subject.keywordMathematical modelsspa
dc.subject.keywordCells - Motilityspa
dc.subject.lembMÉTODO DE ELEMENTOS FINITOSspa
dc.subject.lembANASTOMOSIS ARTERIOVENOSAspa
dc.subject.lembPRÓTESIS DE VASOS SANGUÍNEOSspa
dc.subject.lembANEURISMASspa
dc.subject.lembMATERIALES BIOMÉDICOSspa
dc.subject.lembPOLÍMEROS EN MEDICINAspa
dc.subject.lembCONSERVACIÓN DE TEJIDOSspa
dc.subject.lembDINÁMICA DE FLUIDOSspa
dc.subject.lembMATERIALES POROSOSspa
dc.subject.lembMODELOS MATEMÁTICOSspa
dc.subject.lembMOVILIDAD CELULARspa
dc.titleComputational Study of Cell Mobility and Transport Phenomena Through Textile Vascular Grafts Using a Multi-Scale Approachspa
dc.typedoctoralThesiseng
dc.typeinfo:eu-repo/semantics/doctoralThesiseng
dc.type.hasVersionacceptedVersioneng
dc.type.localTesis Doctoralspa

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Doctorado en Ingeniería (tesis)