Now showing items 1-6 of 6
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart
(Elsevier BV, 2012-02-01)
The aging heart displays a loss of bioenergetic reserve capacity partially mediated through lower fatty acid utilization. We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least ...
Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age
(Elsevier Inc., 2014-07-01)
It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic ...
Characteristics of the Rat Cardiac Sphingolipid Pool in Two Mitochondrial Subpopulations
(Elsevier Inc., 2010-06-01)
Mitochondrial sphingolipids play a diverse role in normal cardiac function and diseases, yet a precise quantification of cardiac mitochondrial sphingolipids has never been performed. Therefore, rat heart interfibrillary ...
(R)-alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria
(Elsevier Inc., 2011-01-01)
Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display ...
Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart
(ELSEVIER SCIENCE INC, 2009-10-01)
Accumulation of mitochondrial electron transport chain (ETC) defects is a recognized hallmark of the age-associated decline in cardiac bioenergetics; however, the molecular events involved are only poorly understood. In ...
Age-related decline in mitochondrial bioenergetics: Does supercomplex destabilization determine lower oxidative capacity and higher superoxide production
Mitochondrial decay plays a central role in the aging process. Although certainly multifactorial in nature, defective operation of the electron transport chain (ETC) constitutes a key mechanism involved in the age-associated ...