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Ítem 2D simulation flue implementing the lattice-boltzmann method(TRANS TECH PUBLICATIONS LTD, 2014-01-01) Ruiz, D.B.; Mesa, A.A.; Alvis, R.G.; Universidad EAFIT. Departamento de Ingeniería de Sistemas; I+D+I en Tecnologías de la Información y las ComunicacionesCurrently in the process of engineering, but increasingly implemented simulation methods since they are an economical and feasible to predict the behavior of some variable you wish to benefit. The problem of fluid simulation is a broad field of study, traditionally in this area are implemented domain discretization methods, volumes, differences or finite elements (Computational Fluid Dynamics), in this work, a different approach where the discretization is made on the physical properties of fluid and the fluid for reconstruction from its microscopic properties, simulating these, propagating Boltzmann distribution functions for the grid of nodes, this set is comprised of a fluid group of nodes, nodes fluid the border and nodes structure, docked the method to the boundary conditions necessary to simulate Glycerol in a pipe. © (2014) Trans Tech Publications, Switzerland.Ítem Two-dimensional transport analysis of transdermal drug absorption with a non-perfect sink boundary condition at the skin-capillary interface(ELSEVIER SCIENCE INC, 2013-07-01) Simon, Laurent; Ospina, Juan; Simon, Laurent; Ospina, Juan; Universidad EAFIT. Departamento de Ciencias; Lógica y ComputaciónA transient percutaneous drug absorption model was solved in two dimensions. Clearance of the topically-applied pharmaceutical occured at the skin-capillary boundary. Timolol penetration profiles in the dermal tissue were produced revealing concentration gradients in the directions normal and parallel to the skin surface. Ninety-eight percent of the steady-state flux was reached after 85. h or four time constants. The analytical solution procedure agreed with published results. As the clearance rate increased relative to diffusion, the delivery rate and amount of drug absorbed into the bloodstream increased while the time to reach the equilibrium flux decreased. Researchers can apply the closed-form expressions to simulate the process, estimate key parameters and design devices that meet specific performance requirements. © 2013 Elsevier Inc.