Maestría en Biociencias (tesis)
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Examinando Maestría en Biociencias (tesis) por Autor "Buitrago Roldán, Nicolás"
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Publicación In Silico Identification of Alternative Molecular Targets from Probiotic Strains for Potential Therapeutic Repositioning in Gut Microbiome-Associated Diseases(Universidad EAFIT, 2025) Buitrago Roldán, Nicolás; García Zea, Jerson Alexander; Sierra Zapata, LauraHuman gut hosts over 100 trillion symbiotic bacteria, far exceeding the number of host cells. These microorganisms collectively form what is known as the gut microbiota. This microbiota performs a wide range of functions crucial for the human body, including protection against pathogens, nutrient extraction, metabolism, and immunity, which, under healthy conditions, result in stability, resilience, and beneficial symbiotic interactions. A probiotic microorganism is defined as a live microorganism that confers a health benefit to the host when administered in adequate amounts. Consequently, in recent years, the number of studies linking probiotic strains to prevent and treat several diseases, such as autoimmune diseases, atopy, metabolic syndrome, metabolic disorders, cancer, and certain behavioral disorders, has increased significantly. Similarly, more research is emerging that employs omics sciences, which involves obtaining comprehensive data that includes genomic, proteomic, metabolic, and other omics information, aiming to assess this data before and after probiotic treatment administration. In this context, and thanks to open access data and cooperative Omics bioinformatic tools, this project proposes an in-silico approach to analyze the effects of probiotic strains on human cells, focusing on differentially expressed genes and their protein-protein interactions. The results highlight the ability of probiotics, such as Propionibacterium freudenreichii ITG P9 and Bacillus subtilis CW14, to modulate human cellular responses, particularly in pathways related to immunity and the cell cycle. This study emphasizes the role of probiotics in regulating genes associated with metabolic, neurological, and autoimmune diseases, revealing potential neuroprotective and antitumoral properties.